മോർഫിൻ

മോർഫിൻ
Clinical data
Trade names	Mscontin, Oramorph, Sevredol(Morphine as a sulfate)
AHFS/Drugs.com	monograph
Pregnancy; category	AU: C ; ;
Dependence; liability	High
Routes of; administration	Inhalation (smoking), insufflation (snorting), oral, rectal, subcutaneous (S.C), intramuscular (I.M), intravenous (I.V), epidural, and intrathecal (I.T.)
ATC code	N02AA01 (WHO) ;
Legal status
Legal status	AU: S8 (Controlled drug); CA: Schedule I; US: Schedule II; UN: Narcotic Schedules I and III; Prescription Medicine Only;
Pharmacokinetic data
Bioavailability	20–40% (oral), 36–71% (rectally), 100% (IV/IM)
Protein binding	30–40%
Metabolism	Hepatic 90%
Elimination half-life	2–3 h
Excretion	Renal 90%, biliary 10%
Identifiers
	IUPAC name (5α,6α)-7,8-didehydro-; 4,5-epoxy-17-methylmorphinan-3,6-diol;
CAS Number	57-27-2 ; 64-31-3 (neutral sulfate),; 52-26-6 (hydrochloride);
PubChem CID	5288826;
IUPHAR/BPS	1627;
DrugBank	DB00295 ;
ChemSpider	4450907 ;
UNII	76I7G6D29C;
KEGG	D08233 ;
ChEBI	CHEBI:17303 ;
ChEMBL	ChEMBL70 ;
CompTox Dashboard (EPA)	DTXSID9023336 ;
ECHA InfoCard	100.000.291
Chemical and physical data
Formula	C17H19NO3
Molar mass	285.34
3D model (JSmol)	Interactive image;
Solubility in water	HCl & sulf.: 60 mg/mL (20 °C)
	SMILES CN1CC[C@]23C4=C5C=CC(O)=C4O[C@H]2[C@@H](O)C=C[C@H]3[C@H]1C5;
	InChI InChI=1S/C17H19NO3/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18/h2-5,10-11,13,16,19-20H,6-8H2,1H3/t10-,11+,13-,16-,17-/m0/s1 ; Key:BQJCRHHNABKAKU-KBQPJGBKSA-N ;
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കറുപ്പിൽ നിന്നും വേർതിരിച്ചേറ്റുക്കുന്ന ശക്തിയേറിയ ഒരു മയക്കുമരുന്നും വേദനാ സംഹാരിയുമാണ് മോർഫിൻ. സ്വപ്നത്തിന്റെ ഗ്രീക്ക് ദേവനായ മോർഫ്യൂസിൽ നിന്നാണ് ആ പേർ ലഭിച്ചത്.

അവലംബം

↑ Jonsson T, Christensen CB, Jordening H, Frølund C (April 1988). "The bioavailability of rectally administered morphine". Pharmacol. Toxicol. 62 (4): 203–5. doi:10.1111/j.1600-0773.1988.tb01872.x. PMID 3387374.{{cite journal}}: CS1 maint: multiple names: authors list (link)

[pmid3387374-1] Jonsson T, Christensen CB, Jordening H, Frølund C (April 1988). "The bioavailability of rectally administered morphine". Pharmacol. Toxicol. 62 (4): 203–5. doi:10.1111/j.1600-0773.1988.tb01872.x. PMID 3387374.{{cite journal}}: CS1 maint: multiple names: authors list (link)

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