ഡെക്സാമെഥസോൺ

ഡെക്സാമെഥസോൺ
Clinical data
Trade names	Dextenza, Ozurdex, others
AHFS/Drugs.com	monograph
MedlinePlus	a682792
License data	EU EMA: yes; US DailyMed: Dexamethasone;
Pregnancy; category	AU: A ; ;
Routes of; administration	By mouth, intravenous therapy (IV), intramuscular injection (IM), subcutaneous injection (IM), intraosseous (IO), eye drop
ATC code	A01AC02 (WHO) C05AA09, D07AB19, D10AA03, H02AB02, R01AD03, S01BA01, S02BA06, S03BA01;
Legal status
Legal status	AU: S4 (Prescription only); CA: ℞-only; UK: POM (Prescription only); US: ℞-only;
Pharmacokinetic data
Bioavailability	80–90%
Protein binding	77%
Metabolism	Liver
Elimination half-life	190 minutes (3.2 hours)
Excretion	Urine (65%)
Identifiers
	IUPAC name (8S,9R,10S,11S,13S,14S,16R,17R)-9- Fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17- dodecahydro-3H-cyclopenta[a]phenanthren-3-one;
CAS Number	50-02-2 ;
PubChem CID	5743;
IUPHAR/BPS	2768;
DrugBank	DB01234 ;
ChemSpider	5541 ;
UNII	7S5I7G3JQL;
KEGG	D00292 ;
ChEBI	CHEBI:41879 ;
ChEMBL	ChEMBL384467 ;
PDB ligand	DEX (PDBe, RCSB PDB);
CompTox Dashboard (EPA)	DTXSID3020384 ;
ECHA InfoCard	100.000.004
Chemical and physical data
Formula	C22H29FO5
Molar mass	392.461 g/mol
3D model (JSmol)	Interactive image;
Melting point	262 °C (504 °F)
	SMILES O=C(CO)[C@]3(O)[C@]2(C[C@H](O)[C@]4(F)[C@@]/1(\C(=C/C(=O)\C=C\1)CC[C@H]4[C@@H]2C[C@H]3C)C)C;
	InChI InChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1 ; Key:UREBDLICKHMUKA-CXSFZGCWSA-N ;
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ഒരു കോർട്ടിക്കോ സ്റ്റീറോയ്ഡ് മരുന്നാണ് ഡെക്സാമെഥസോൺ(Dexamethasone) .^[1] സന്ധിവാതം, ചർമ്മരോഗങ്ങൾ, അലർജി, ആസ്മ, ക്രൂപ്പ്, മസ്തിഷ്കവീക്കം, കോവിഡ്-19, നേത്രശസ്ത്രകിയയുടെ ഫലമായുണ്ടാകുന്ന കണ്ണുവേദന, ക്ഷയം എന്നിവയ്ക്ക് ഈ മരുന്ന് നൽകപ്പെടുന്നു.^[1]

അവലംബം

↑ ^1.0 ^1.1 "Dexamethasone". The American Society of Health-System Pharmacists. Archived from the original on 2017-08-31. Retrieved Jul 29, 2015.

[AHFS2015-1] 1.0 ^1.1 "Dexamethasone". The American Society of Health-System Pharmacists. Archived from the original on 2017-08-31. Retrieved Jul 29, 2015.

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