പ്രോസ്റ്റാഗ്ലാൻഡിൻ EP3 റിസപ്റ്റർ
ലുവ പിഴവ് ഘടകം:Infobox_gene-ൽ 2693 വരിയിൽ : variable 'return_val' is not declared
പ്രോസ്റ്റാഗ്ലാൻഡിൻ EP3 റിസപ്റ്റർ (53kDa), ഇപി 3 എന്നും അറിയപ്പെടുന്നു, മനുഷ്യ ജീൻ PTGER3 എൻകോഡ് ചെയ്തിട്ടുള്ള പ്രോസ്റ്റാഗ്ലാൻഡിൻ E2 (PGE2) പ്രോസ്റ്റാഗ്ലാൻഡിൻ റിസപ്റ്റർ ആണ്.[1]ഇത് തിരിച്ചറിഞ്ഞിട്ടുള്ള നാല് ഇപി റിസപ്റ്ററുകളിൽ ഒന്നാണ്. മറ്റുള്ളവ EP1, EP2, EP4 എന്നിവയാണ്. ഇവയെല്ലാം PGE2- നും സെല്ലുലാർ പ്രതികരണങ്ങളുമായി ബന്ധിപ്പിക്കുകയും മധ്യസ്ഥം ആയി പ്രതിപ്രവർത്തിക്കുകയും ചെയ്യുന്നു. എന്നാൽ പൊതുവേ ചെറിയ ഘടനാസാദൃശ്യവും പ്രതികരണവുമൊക്കെയുള്ള പ്രോസ്റ്റാനോയിഡുകൾ (പ്രോസ്റ്റാഗ്ലാൻഡിൻ റിസപ്റ്റർ കാണുക).ആണ്.[2] ഇപി വിവിധതരം ശാരീരികവും രോഗകാരകവുമായ പ്രതികരണങ്ങളെ സൂചിപ്പിക്കുന്നു.[3]
ഇതും കാണുക
തിരുത്തുകഅവലംബം
തിരുത്തുക- ↑ https://www.ncbi.nlm.nih.gov/gene/5733
- ↑ "Entrez Gene: PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa".
- ↑ Woodward DF, Jones RL, Narumiya S (September 2011). "International Union of Basic and Clinical Pharmacology. LXXXIII: classification of prostanoid receptors, updating 15 years of progress". Pharmacological Reviews. 63 (3): 471–538. doi:10.1124/pr.110.003517. PMID 21752876.
കൂടുതൽ വായനയ്ക്ക്
തിരുത്തുക- Kotani M, Tanaka I, Ogawa Y, Usui T, Mori K, Ichikawa A, Narumiya S, Yoshimi T, Nakao K (November 1995). "Molecular cloning and expression of multiple isoforms of human prostaglandin E receptor EP3 subtype generated by alternative messenger RNA splicing: multiple second messenger systems and tissue-specific distributions". Molecular Pharmacology. 48 (5): 869–79. PMID 7476918.
- Han X, Lan X, Li Q, Gao Y, Zhu W, Cheng T, Maruyama T, Wang J (June 2016). "Inhibition of prostaglandin E2 receptor EP3 mitigates thrombin-induced brain injury". Journal of Cerebral Blood Flow and Metabolism. 36 (6): 1059–74. doi:10.1177/0271678X15606462. PMID 26661165.
- Duncan AM, Anderson LL, Funk CD, Abramovitz M, Adam M (February 1995). "Chromosomal localization of the human prostanoid receptor gene family". Genomics. 25 (3): 740–2. doi:10.1016/0888-7543(95)80022-E. PMID 7759114.
- Schmid A, Thierauch KH, Schleuning WD, Dinter H (February 1995). "Splice variants of the human EP3 receptor for prostaglandin E2". European Journal of Biochemistry. 228 (1): 23–30. doi:10.1111/j.1432-1033.1995.tb20223.x. PMID 7883006.
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- Regan JW, Bailey TJ, Donello JE, Pierce KL, Pepperl DJ, Zhang D, Kedzie KM, Fairbairn CE, Bogardus AM, Woodward DF (June 1994). "Molecular cloning and expression of human EP3 receptors: evidence of three variants with differing carboxyl termini". British Journal of Pharmacology. 112 (2): 377–85. doi:10.1111/j.1476-5381.1994.tb13082.x. PMC 1910333. PMID 8075855.
- Yang J, Xia M, Goetzl EJ, An S (February 1994). "Cloning and expression of the EP3-subtype of human receptors for prostaglandin E2". Biochemical and Biophysical Research Communications. 198 (3): 999–1006. doi:10.1006/bbrc.1994.1142. PMID 8117308.
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- Kotani M, Tanaka I, Ogawa Y, Usui T, Tamura N, Mori K, Narumiya S, Yoshimi T, Nakao K (March 1997). "Structural organization of the human prostaglandin EP3 receptor subtype gene (PTGER3)". Genomics. 40 (3): 425–34. doi:10.1006/geno.1996.4585. PMID 9073510.
- Ushikubi F, Segi E, Sugimoto Y, Murata T, Matsuoka T, Kobayashi T, Hizaki H, Tuboi K, Katsuyama M, Ichikawa A, Tanaka T, Yoshida N, Narumiya S (September 1998). "Impaired febrile response in mice lacking the prostaglandin E receptor subtype EP3". Nature. 395 (6699): 281–4. doi:10.1038/26233. PMID 9751056.
- Bhattacharya M, Peri K, Ribeiro-da-Silva A, Almazan G, Shichi H, Hou X, Varma DR, Chemtob S (May 1999). "Localization of functional prostaglandin E2 receptors EP3 and EP4 in the nuclear envelope". The Journal of Biological Chemistry. 274 (22): 15719–24. doi:10.1074/jbc.274.22.15719. PMID 10336471.
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ബാഹ്യ ലിങ്കുകൾ
തിരുത്തുക- "Prostanoid Receptors: EP3". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-06-29.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.