ഐസോനിയാസിഡ്

ഐസോനിയാസിഡ്
Clinical data
Trade names	Hydra, Hyzyd, Isovit, other
Other names	isonicotinic acid hydrazide, isonicotinyl hydrazine, INHA
AHFS/Drugs.com	monograph
MedlinePlus	a682401
Routes of; administration	by mouth, intramuscular, intravenous
ATC code	J04AC01 (WHO) ;
Legal status
Legal status	US: WARNINGrx only;
Pharmacokinetic data
Protein binding	Very low (0–10%)
Metabolism	liver; CYP450: 2C19, 3A4 inhibitor
Elimination half-life	0.5–1.6h (fast acetylators), 2-5h (slow acetylators)
Excretion	urine (primarily), feces
Identifiers
	IUPAC name Pyridine-4-carbohydrazide;
CAS Number	54-85-3 ;
PubChem CID	3767;
DrugBank	DB00951 ;
ChemSpider	3635 ;
UNII	V83O1VOZ8L;
KEGG	D00346 ;
ChEBI	CHEBI:6030 ;
ChEMBL	ChEMBL64 ;
NIAID ChemDB	007657;
CompTox Dashboard (EPA)	DTXSID8020755 ;
ECHA InfoCard	100.000.195
Chemical and physical data
Formula	C6H7N3O
Molar mass	137.139 g/mol
3D model (JSmol)	Interactive image;
	SMILES O=C(NN)c1ccncc1;
	InChI InChI=1S/C6H7N3O/c7-9-6(10)5-1-3-8-4-2-5/h1-4H,7H2,(H,9,10) ; Key:QRXWMOHMRWLFEY-UHFFFAOYSA-N ;
	(verify)

ക്ഷയരോഗത്തിന് നിലവിലുള്ള മരുന്നുകളിൽ ഒന്നാണ് ഐസോനിയാസിഡ്.^[3] ക്ഷയത്തിന് ഇത് റിഫാംപിസിൻ, പൈറാസിനമൈഡ്, സ്ട്രെപ്റ്റോമൈസിൻ അല്ലെങ്കിൽ എത്താംബ്യൂട്ടോൾ എന്നിവയ്ക്കൊപ്പം ഉപയോഗിക്കുന്നു.

അവലംബം

↑ "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 Oct 2023.
↑ "Isoniazid". The American Society of Health-System Pharmacists. Archived from the original on 20 December 2016. Retrieved 8 December 2016.
↑ "Isoniazid". The American Society of Health-System Pharmacists. Archived from the original on 20 December 2016. Retrieved 8 December 2016.

Core Curriculum on Tuberculosis (2000) Division of Tuberculosis Elimination, Centers for Disease Control and Prevention

See Chapter 6, Treatment of LTBI Regimens – Isoniazid::
See Chapter 7 – Treatment of TB Disease Monitoring – Adverse Reactions to First-line TB Drugs – Isoniazid::
See Table 5 First-Line Anti-TB Medications