അമിട്രിപ്ടൈലിൻ

അമിട്രിപ്ടൈലിൻ
Clinical data
Pronunciation	/ˌæmɪˈtrɪptɪliːn/
Trade names	Amitrip, Elavil, Endep, Levate
AHFS/Drugs.com	monograph
MedlinePlus	a682388
License data	US FDA: Amitriptyline;
Pregnancy; category	AU: C ; ;
Routes of; administration	Oral, intramuscular
ATC code	N06AA09 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only); CA: ℞-only; UK: POM (Prescription only); US: WARNINGRx-only;
Pharmacokinetic data
Bioavailability	30–60% due to first pass metabolism
Protein binding	96%<
Metabolism	Liver
Elimination half-life	10 to 50 hrs
Excretion	Mostly kidney
Identifiers
	IUPAC name 3-(10,11-Dihydro-5H-dibenzo[a,d]cycloheptene-5-ylidene)-N,N-dimethylpropan-1-amine;
CAS Number	50-48-6 ; 549-18-8 (hydrochloride);
PubChem CID	2160;
IUPHAR/BPS	200;
DrugBank	DB00321 ;
ChemSpider	2075 ;
UNII	1806D8D52K;
KEGG	D07448 ;
ChEBI	CHEBI:2666 ;
ChEMBL	ChEMBL629 ;
CompTox Dashboard (EPA)	DTXSID7022594 ;
ECHA InfoCard	100.000.038
Chemical and physical data
Formula	C20H23N
Molar mass	277.403 g/mol
3D model (JSmol)	Interactive image;
	SMILES c3cc2c(/C(c1c(cccc1)CC2)=C\CCN(C)C)cc3;
	InChI InChI=1S/C20H23N/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20/h3-6,8-12H,7,13-15H2,1-2H3 ; Key:KRMDCWKBEZIMAB-UHFFFAOYSA-N ;
	(verify)

അമിട്രിപ്ടൈലിൻ ഒരു മാനസികരോഗങ്ങൾക്കുപയോഗിക്കുന്ന മരുന്ന് ആകുന്നു. ഡിപ്രഷൻ, ആകാംഷാരോഗം, ശ്രദ്ധ കേന്ദ്രീകരിക്കാനാവാത്ത വസ്ഥ, ഹൈപ്പർ ആക്റ്റിവിറ്റി ഡിസോഡർ, ബൈപൊളാർ ഡിസോർഡർ തുടങ്ങിയവയ്ക്കള്ള ചികിത്സയ്ക്കായി ഉപയൊഗിക്കുന്നു.

↑ "Oxford Dictionary: Definition of amitriptyline (British & World English)". Archived from the original on 2014-07-14. Retrieved 2016-10-13. Archived 2014-07-14 at the Wayback Machine.
↑ "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 Oct 2023.
↑ ^3.0 ^3.1 ^3.2 ^3.3 "Amitriptyline Hydrochloride". The American Society of Health-System Pharmacists. Archived from the original on 2014-09-24. Retrieved Sep 25, 2014.

[1] "Oxford Dictionary: Definition of amitriptyline (British & World English)". Archived from the original on 2014-07-14. Retrieved 2016-10-13. Archived 2014-07-14 at the Wayback Machine.

[FDA-AllBoxedWarnings-2] "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 Oct 2023.

[AHFS2014-3] 3.0 ^3.1 ^3.2 ^3.3 "Amitriptyline Hydrochloride". The American Society of Health-System Pharmacists. Archived from the original on 2014-09-24. Retrieved Sep 25, 2014.

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[2]

[3]

Clinical data


Pronunciation	/ˌæmɪˈtrɪptɪliːn/^[1]
Trade names	Amitrip, Elavil, Endep, Levate
AHFS/Drugs.com	monograph
MedlinePlus	a682388
License data	US FDA: Amitriptyline
Pregnancy category	AU: C
Routes of administration	Oral, intramuscular
ATC code	N06AA09 (WHO)
Legal status
Legal status	AU: S4 (Prescription only) CA: ℞-only UK: POM (Prescription only) US: WARNING^[2]Rx-only
Pharmacokinetic data
Bioavailability	30–60% due to first pass metabolism
Protein binding	96%<^[3]
Metabolism	Liver^[3]
Elimination half-life	10 to 50 hrs^[3]
Excretion	Mostly kidney^[3]
Identifiers
IUPAC name 3-(10,11-Dihydro-5H-dibenzo[a,d]cycloheptene-5-ylidene)-N,N-dimethylpropan-1-amine
CAS Number	50-48-6^Y 549-18-8 (hydrochloride)
PubChem CID	2160
IUPHAR/BPS	200
DrugBank	DB00321^Y
ChemSpider	2075^Y
UNII	1806D8D52K
KEGG	D07448^Y
ChEBI	CHEBI:2666^Y
ChEMBL	ChEMBL629^Y
CompTox Dashboard (EPA)	DTXSID7022594
ECHA InfoCard	100.000.038
Chemical and physical data
Formula	C₂₀H₂₃N
Molar mass	277.403 g/mol
3D model (JSmol)	Interactive image
SMILES c3cc2c(/C(c1c(cccc1)CC2)=C\CCN(C)C)cc3
InChI InChI=1S/C20H23N/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20/h3-6,8-12H,7,13-15H2,1-2H3^Y Key:KRMDCWKBEZIMAB-UHFFFAOYSA-N^Y
(verify)